Welcome to this special mini-guide referent projects in the field of DESCI (or decentralized science in French). This fairly recent movement is a key player for the rescue of current health systems and could revolutionize science. What you enlighten on this web3 subject which will undoubtedly mark a turning point for new generations and their health.
The DESCI offers a new approach to science
No one is without knowing that science continues to progress every day through new discoveries. However, if we look more closely, it is quite easy to see that scientific progress could advance much faster. For what ? Because Current science is centralized.
Research is placed in the hands of some organizations (government figures, large companies, or even large publishing houses of scientific newspapers) then posing a problem of governance and transparency for those who really make these advances live.
The decentralization of science is the assurance of a more transparent sciencemore collaborative and so community. It is the hope of seeing thousands of results from scientific research made visible and accessible to everyone. And of course, all this with a single goal: to advance scientific progress, and therefore medical progress faster, further. Take care yes, but above all anticipate care, and save global. In short, a virtuous circle.
There Desci seeks to recondate the way of finance, govern and share science via :
- DAOS (decentralized autonomous organizations) which abound projects;
- “Tokenized” intellectual property and open publications with incentives;
- or EHR (Electronic Health Records or DPI for computerized patient file in French) connected to citizen communities.
But then, if this movement is so revolutionary, where is it? What are the actors who make it grow? What are the main projects that make it live? What do they do concretely? Here is a detailed light on the TOP 5 DESCI projects in 2025 and 2026 (really deployed funds, public portfolios, historic IP-NFT, calls for operational projects, active platforms).
1/ Vitadao – Dao longevity that finances, publishes and follows projects
What does Vitadao offer?
Vitadao is a DAO (decentralized Autonomous Organization) dedicated to the longevity sciences: it identifies translational and finance research avenues from teams via web3 mechanisms, with a public portfolio of projects. Several million dollars have been deployed and around twenty projects funded, with transparency on cash and governance.
How does it work?
The researchers apply, a Dealflow assesses, then the community votes and finances; Monitoring is then published (blogs, governance forum). The indicators displayed on the site (deployed funds, projects, community) make it one of the few cases of the consolidated and sustainable assessment.
Why join the project?
If you are fascinated by questions dealing with longevity, and if the financing open and the transfer of PI (intellectual property) to biotechs interests you.
2/ Galeon – The DAO brings together health professionals and patients
What does Galeon offer?
Galeon is a French project that has given itself a precise mission:
- Make scientific research take off by standardizing the data of hospitals wherever it is harvested;
- Propose a solid health management (PHM) population to anticipate and treat different diseases.
With his Dao, Galeon adds a community layer to the DESCI sauce: his community can participate in scientific research on his Atlantis gamified platform And ensure value sharing thanks to its token, the $ Galeon. A real bridge between hospitals, caregivers, patients and contributors.
How does it work?
Galeon Hyperstructure and secures medical sensitive data via his computerized patient file, thanks to AI and Blockchain. The latter, deployed in almost twenty French hospitals, ensures the interoperability of the data between the latter. Its owner technology allows AI decentralized training on blockchain on a very large number of data to boost research.
His Atlantis project, he federates a community of “pioneers” around actions (quests, support for projects, governance).
Why join the project?
If you are interested in hospital interoperability, medical AI and an applied DESCI from the patient's bed, where structured data fuel concrete research while respecting confidentiality. Or simply if health subjects affect you directly or indirectly, without being an expert.
3/ Molecule-The IP-NFT/ IP-TOKENS infrastructure which has “industrialized” the intellectual proof
What does MOLECLE offer?
Molecule offers an infrastructure that “packs” intellectual or “pi” property assets (patents, datasets, license agreements) in IP-NFT, and can split them into IP-Tukens to finance, govern and transfer these rights more effectively (IP = Intellectual Property). It is a brick used by several biodao (like Vitadao, Athenadao…).
How does it work?
Founding case: First IP-NFT Biopharma sold to Vitadao in August 2021, demonstrating the so-chain transferability of a university license agreement-a historic milestone of the DESCI. Since then, Molecule has been documenting iterations (IP-NFT V2) and collaborations.
Why join the project?
If you are interested in the tokenization of the PI, the research asset markets and the shared governance of scientific results.
4/ Researchhub – An “economy” of open publication with reviews remuneration
What does ResearchHub offer?
Researchhub Building a publication and rereading platform where contributions (summaries, reviews, bounties, for digital objects identifiers) are encouraged by the RSC token. The objective: to accelerate the dissemination of reproducible work while paying the rereaders and facilitating micro-finance.
How does it work?
Users create bounties (e.g. “peer-review” of a preprint) and are paid in token RSC according to public scales; The documentation specifies the typical amounts and the framework for using token. The activity is visible via the Foundation and the updated documents.
Why join the project?
If you are interested in pragmatic open-science, remunerated rereading and micro-guys directly backed by scientific tasks.
5/ Athenadao-The DESCI dedicated to women's health (Cohortes & First IP-NFT)
What does Athenadao offer?
Athenadao Concentrates DESCI funding on women's health (reproductive Longevity, Reputech, etc.). The project funded a first IP-NFT and regularly announces collaborations and calls for projects, with clear communication (site, substack, press kit).
How does it work?
The mechanism combines calls for projects (e.g. Cohort 4 opened on reputech), selection by DAO, then funding (subsidies/IP-NFT) and quarterly reporting. The first aggregated financial commitments (> $ 250 k on the initial phase) were publicly detailed.
Why join this project?
If you are passionate about biomedical research centered on the needs of women, reproductology and innovation open at the service of a long underfallocated field.
So much for the main DESCI projects which today carry this promising movement and which make it live. Some are more developed than others, for lack of sufficient funding. However, there is everything to hope that others are born shortly and help science to transition from centralization to a necessary decentralization. Because the latter must be written collectively.
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